Patients with a confirmed or suspected diagnosis of hypophosphatasia should be referred to an individualised management team, which may include:
Due to the unique pathophysiology of the disease, surgical repair may differ for patients with hypophosphatasia. Experts recommend managing pseudofractures secondary to hypophosphatasia by internal fixation with a load-bearing device without removal1,5,6
Reprinted with permission from Whyte, Principles of Bone Biology, 3rd ed, 2008.
Reprinted with permission from Berkseth et al., 2013.