Adult Case

Fatal nephrocalcinosis resulting from paediatric-onset HPP in a female adult1

After surviving infantile hypophosphatasia, a young woman progresses to early death from impaired calcium regulation and nephrocalcinosis.

Severe, systemic manifestations of hypophosphatasia can lead to premature death in patients of all ages.1,3

Based on a published case study: Eade et al, Ann Rheum Dis, 1981.

References:
  1. Eade AWT, Swannell AJ, Williamson N. Pyrophosphate arthropathy in hypophosphatasia. Ann Rheum Dis. 1981;40(2):164-170.
  2. Rickets. MedlinePlus website. https://www.nlm.nih.gov/medlineplus/ency/article/000344.htm. Updated August 30, 2014. Accessed June 8, 2016.
  3. Whyte MP, Leelawattana R, Reinus WR, Yang C, Mumm S, Novack DV. Acute severe hypercalcemia after traumatic fractures and immobilization in hypophosphatasia complicated by chronic renal failure. J Clin Endocrinol Metab. 2013;98(12):4606-4612.