Patients with a confirmed or suspected diagnosis of hypophosphatasia should be referred to an individualized management team, which may include:
Due to the unique pathophysiology of the disease, surgical repair may differ for patients with hypophosphatasia. Experts recommend managing pseudofractures secondary to hypophosphatasia by internal fixation with a load-bearing device without removal1,5,6
Reprinted with permission from Whyte, Principles of Bone Biology, 3rd ed, 2008.
Reprinted with permission from
Berkseth et al., 2013.
Misdiagnosis can lead to ineffective management that can compound clinical consequences.1-4
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