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Delayed Diagnosis

Lifelong, progressive manifestations of HPP in a male adult1

Skeletal and systemic manifestations lead to worsening physical impairment in a man with hypophosphatasia.

Chronic, progressive, systemic consequences of hypophosphatasia can result in acute catastrophic events that increase risk of mortality throughout life.

Based on a published case study: Whyte et al, J Clin Endocrinol Metab, 2013.

aNormal ALP reference interval used by the laboratory in this case study was 28-88 IU/L. Please note that reference intervals can vary among laboratories.

bNormal PEA reference interval used by the laboratory in this case study was 26-101 μmol/dL. Please note that reference intervals can vary among laboratories.

cNormal serum calcium reference interval used by the laboratory in this case study was 8.6-10.3 mg/dL. Please note that reference intervals can vary among laboratories.

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References:
  1. Whyte MP, Leelawattana R, Reinus WR, Yang C, Mumm S, Novack DV. Acute severe hypercalcemia after traumatic fractures and immobilization in hypophosphatasia complicated by chronic renal failure. J Clin Endocrinol Metab. 2013;98(12):4606-4612.