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Progressive Case 2

Progressive pain and disability in a female adult with hypophosphatasia1

A woman with hypophosphatasia experiences a lifetime of pain.

Over time, progressive skeletal damage can result in increasingly severe manifestations in adults with hypophosphatasia.1,2

Based on a published case study: Whyte et al, Am J Med, 1982.

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References:
  1. Whyte MP, Murphy WA, Fallon MD. Adult hypophosphatasia with chondrocalcinosis and arthropathy. Variable penetrance of hypophosphatasemia in a large Oklahoma kindred. Am J Med. 1982;72(4):631-641.
  2. Silva I, Castelão W, Mateus M, Branco JC. Childhood hypophosphatasia with myopathy: clinical report with recent update. Acta Rheumatol Port. 2012;37(1):92-96.