With hypophosphatasia (HPP), daily tasks can become lifelong challenges.

Beyond damaging bones and organs, HPP can have lasting effects on a person’s everyday life. In children, HPP can lead to slow or stunted growth and can also delay or interfere with normal development. Children with HPP may be slow to crawl, stand, and walk. Adults can also have mobility issues.

Activities that may be challenging for people with HPP:

FOR CHILDREN Keeping up with friends or walking around school
FOR ADULTS Getting to and from work or doing daily errands and tasks
FOR CHILDREN Playing with friends or playing sports
FOR ADULTS Exercising, playing sports, or keeping up with children
FOR CHILDREN Standing comfortably at school or social events
FOR ADULTS Standing for long periods of time at work or social events
FOR CHILDREN Moving around their own home, at friends' houses, or at school
FOR ADULTS Moving around their own home or in public spaces with multiple floors
FOR CHILDREN Carrying schoolbooks, toys, or items around the house
FOR ADULTS Carrying children, cleaning the house, or doing errands such as grocery shopping
FOR CHILDREN Being awake and alert during the school day
FOR ADULTS Staying awake and alert during the work day or while caring for children

HPP can impact growth and development.

Growth

  • Children with HPP may experience slow or stunted growth
  • Children with HPP may weigh less than other children of the same age (failure to thrive)
  • Bones such as the skull and rib cage may grow abnormally
  • Bones in the arms and legs may be shorter in proportion to the rest of the body

Development

  • Children with HPP may not be able to do basic activities as early or as easily as other children
  • Children with HPP can have difficulty holding and carrying objects
  • Children with HPP may be slow to crawl, stand, and walk