What is hypophosphatasia (HPP)?

Hypophosphatasia (hypo-fahs-fuh-TAY-shuh), or HPP, is a progressive disease with a lifelong impact.

Who can get HPP?

HPP is an uncommon disease, but it can affect men and women of any age, from infancy through adulthood. Some people with HPP are diagnosed as children, while others are diagnosed as adults.

Some quick facts about HPP


  • It is progressive, so symptoms may get worse over time
  • New symptoms can appear at any age
  • People with HPP can experience signs and symptoms in their bones, muscles, joints, teeth, lungs, brain, and kidneys
  • HPP is often misdiagnosed as other more common diseases
  • It is an inherited disease that can damage bones and bodies