Hypophosphatasia (HPP) is often misdiagnosed.

People with HPP can experience a number of different symptoms, and many of these symptoms—such as weak or brittle bones or frequent fractures—are also symptoms of other more common diseases. People with HPP are often misdiagnosed because many doctors do not have experience with HPP.

Below are other diseases that have symptoms that can look like HPP.

Diseases that can look like HPP
SYMPTOMS SHARED WITH HPP:DISEASES:
WEAK BONES
  • Rickets (nutritional rickets and X‑linked hypophosphatemic rickets)
  • Osteopenia/osteoporosis 
  • Osteogenesis imperfecta
  • Osteomalacia
CHRONIC PAIN AND JOINT PROBLEMS
  • Osteoarthritis/arthritis
  • Rheumatoid arthritis
  • Leukemia or bone cancer
  • Fibromyalgia
  • Pseudogout
TOOTH LOSS
  • Gum disease
  • Dentinogenesis imperfecta

Diseases in bold are the most common misdiagnoses.