Get an accurate diagnosis.

Get the best care.

Getting an accurate diagnosis of hypophosphatasia (HPP) from your physician helps to ensure that you receive specialized care. It also helps prevent your doctor from giving you medications that do not help your condition—and could actually be harmful to someone with HPP.

Once I am diagnosed with HPP, what can my doctor do?

If you have been diagnosed with HPP, your doctor may

  • Prescribe medication to help you manage bone, muscle, and joint pain
  • Recommend specific dental care to keep your teeth and gums healthy
  • Consult with your orthopedic surgeons on how to perform surgery in a way that keeps weak and soft bones stable

What types of medications could be harmful for someone with HPP?

People with HPP should avoid

  • Calcium supplements
  • Vitamin D supplements
  • Phosphate supplements (such as bisphosphonates)

These medications—which may be given to someone who is misdiagnosed with other similar disorders—can make some symptoms of HPP worse.

People with HPP cannot properly process minerals such as calcium, vitamin D, and phosphate. Adding additional minerals can lead to growth failure, bone lesions, and calcium deposits in the kidneys. Once a patient stops taking the medications, their health may improve.