How would a healthcare provider diagnose hypophosphatasia (HPP)?

The key to a correct diagnosis is hiding in plain sight. A review of a standard blood test called a comprehensive blood panel could be the answer to an HPP diagnosis:

Persistently low age- and sex-adjusted ALP + at least one HPP symptom may be enough for a doctor to diagnose HPP, even in kids.

A doctor should rule out all other causes of low ALP, and a diagnosis should always be made by a qualified healthcare professional.