“Can a doctor tell me why my body feels this way?”

Even though hypophosphatasia (HPP) is a rare condition, a simple blood test can provide the answer:
Persistently low age- and sex-adjusted alkaline phosphatase (ALP), plus one or more HPP symptoms, may be enough to confirm an HPP diagnosis. Check with your doctor for more information. Only a licensed healthcare professional can diagnose HPP.*

*after your doctor has ruled out other causes of low ALP

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What is alkaline phosphatase (ALP)?

ALP is an enzyme in the body that is crucial for the development of strong, healthy bones. People with HPP have persistently low ALP, which contributes to many symptoms of the condition, including frequent bone injuries. It’s important to adjust for age and sex when assessing ALP to arrive at the most accurate possible reference range, especially in children.

More on ALP

How do I know if my
diagnosis is correct?

HPP is commonly misdiagnosed as these conditions.

Frequently in adults, HPP is mistaken for other more common conditions. If you feel something is wrong, and believe your symptoms could mean something more, don’t settle. A doctor can diagnose HPP with the help of a blood test.

neck pain

Chronic Conditions

Brain Fog

bone pain

Bone Pain

Osteogenesis Imperfecta
Rheumatoid Arthritis

tooth loss

Tooth Loss

Gum Disease
Dentinogenesis Imperfecta



Bone Cancer

How is hpp diagnosed?

What steps can I take with my child’s doctor to test my child for HPP?

Having a child who doesn’t gain weight, grow on pace, or meet expected milestones can be a sign that something’s not right. Ask your child’s doctor for a blood test to determine if your child has persistently low ALP.

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