What factors can lead to a hypophosphatasia (HPP) diagnosis in adults?

While symptoms like fatigue, brain fog, or joint pain could be signs of HPP, there’s one factor that will most likely confirm a diagnosis. It can feel complex, but a diagnosis doesn’t have to be complicated.

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If you’ve lived a lifetime with unexplained, seemingly disconnected symptoms, it is time to talk to a doctor about getting a diagnosis. Ask your doctor for a simple blood test to determine if you have HPP.

One or more HPP symptoms + persistently low age- and sex-adjusted ALP


Persistently low
Age- and sex-adjusted alp

HPP Symptoms

One or more HPP


May be enough for your
doctor to diagnose HPP

If you or your doctor suspect HPP based on your symptoms and history,
a blood test to check your ALP levels can help your doctor confirm the diagnosis. Check with your doctor
for more information, only a licensed healthcare professional can diagnose HPP.*

*After your doctor has ruled out other causes of low ALP

Learn More About ALP

Seek Answers. Take action.

Are you tired of your unexplained symptoms? It’s not too late to make a change.

Know Your Symptoms.

HPP is difficult to diagnose in adults because of shared symptoms with more common bone or rheumatologic diseases, like arthritis. But while it may seem easier to brush off or minimize your pain—especially if you’ve normalized it over your lifetime—it’s never too late to be proactive. Don’t wait another minute. Have a conversation with your doctor.

Get the Right Answers.

If you feel like you’ve been misdiagnosed, you’re not alone. The list of misdiagnoses for HPP is long and can include more common conditions, like rickets, fibromyalgia, and sometimes even gum disease.

Get the Help You Deserve.

When going to the doctor, bring your medical records with you (if possible). Or, talk to your parents, caregiver, or older siblings to go over events and symptoms from your childhood.

Medical History

During your life, have you experienced unexplained fractures? Or premature tooth loss with the root intact? Every person’s medical history is unique and can be the key to unlocking an accurate diagnosis. Tracking your symptoms over time and sharing them with your doctor may lead to an earlier diagnosis.

Personal Records

If you have access to your personal medical records, they can be very helpful in receiving a correct diagnosis. Bring them to your next appointment.

Significant Medical Events

Did you experience any significant injuries during childhood? Any major medical milestones to note? Consult a parent or guardian, and make sure to mention these significant events to your doctor.


Write down a list of questions you have and ask them! The best way to get answers about your symptoms—and potential diagnosis—is to have an open, honest conversation with your doctor.


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