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In hypophosphatasia (HPP), premature tooth loss is a common presenting symptom.1-7

Image courtesy of Research Center, Shriners Hospitals for Children—St. Louis
Left: Incisor with root intact from patient with hypophosphatasia. Right: Incisor with root absorbed.

In hypophosphatasia, defective acellular root cementum results in compromised peridontal attachment.1,8,9 Patients may experience2-9:

Premature tooth loss—with the root intact—before the age of five
Nontraumatic tooth loss at any age

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