Register

Today

For Valuable Updates and Resources

Renal

Clinical snapshot

In a natural history study of patients ≤5 years of age with hypophosphatasia (HPP)1,a:

52% (16/31) of patients had nephrocalcinosis

Patients with hypophosphatasia (HPP) can suffer from profound renal manifestations.2-6

In hypophosphatasia, defective bone mineralization and impaired regulation of phosphate and calcium can result in renal manifestations.2-5

Patients with hypophosphatasia may experience2-4

Hypercalcemia
Hypercalciuria
Hyperphosphatemia

Elevation of calcium can result in2,4,5

Nephrocalcinosis
Renal damage, which may be severe

Systemic manifestations of hypophosphatasia can include severe renal damage and renal failure.2,4,5

aData from a noninterventional, retrospective chart review study designed to understand the natural history of 48 patients with severe perinatal- and infantile-onset hypophosphatasia ≤5 years of age.1

By clicking "SUBMIT" I agree to the Privacy Notice and Terms of Use.