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aThe HPP Impact Patient Survey (HIPS) was an Internet questionnaire that queried demographics, hypophosphatasia-related illness history, disease progression, and health-related quality of life. One hundred thirty-three patients participated.2
bData from a retrospective, noninterventional substudy of children (n=6) enrolled in a larger retrospective, multinational, noninterventional natural history study of childhood hypophosphatasia (N=32).3
cData from a noninterventional, retrospective chart review study designed to understand the natural history of 48 patients with severe perinatal- and infantile-onset hypophosphatasia ≤5 years of age.20
dData from a retrospective, multinational, noninterventional natural history study of childhood hypophosphatasia (N=32).21
eHIPS/HPP Outcomes Survey Telephone (HIPS/HOST) combined data from an Internet questionnaire and telephone survey that queried demographics, hypophosphatasia-related illness history, disease progression, and health-related quality of life. One hundred eighty-four patients participated (59 children, 125 adults).1,2
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