Delayed Diagnosis

Lifelong, progressive manifestations of HPP in a male adult¹

Skeletal and systemic manifestations lead to worsening physical impairment in a man with hypophosphatasia.

Infographic showing skeletal and systemic manifestations leading to worsening physical impairment in a patient with hypophosphatasia, resulting in death from recurrent sepsis

Chronic, progressive, systemic consequences of hypophosphatasia can result in acute catastrophic events that increase risk of mortality throughout life.

Based on a published case study: Whyte et al, J Clin Endocrinol Metab, 2013.

^aNormal ALP reference interval used by the laboratory in this case study was 28-88 IU/L. Please note that reference intervals can vary among laboratories.

^bNormal PEA reference interval used by the laboratory in this case study was 26-101 μmol/dL. Please note that reference intervals can vary among laboratories.

^cNormal serum calcium reference interval used by the laboratory in this case study was 8.6-10.3 mg/dL. Please note that reference intervals can vary among laboratories.

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