The devastating consequences of hypophosphatasia in adults

Manifestations of hypophosphatasia in adults can include

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Skeletal
Muscular/Rheumatologic
Physical function
Dental
Renal

Loss of physical function impacting activities of daily living¹⁵

Unusual gait¹⁵

Impaired mobility (including the need for assistive devices such as wheelchair, walker, crutches, or cane)^1,15

Alkaline phosphatase (ALP) is necessary for ongoing skeletal health because of the body’s constant bone mass turnover.^1,5,21,22

Skeletal manifestations of hypophosphatasia can result in a high burden of disease in adults.¹

55 years of age^23,a

56 years²⁴ of age^18,a

$Pelvic radiograph showing bilateral acute subtrochanteric femoral fractures$

$Radiograph of the foot showing metatarsal stress fracture$

Bilateral acute subtrochanteric femoral fractures

Recurrent, poorly healing metatarsal stress fracture

32 years of age^25,a

55 years of age^26,a

$Radiograph showing a pseudofracture of the distal fibula$

$Radiograph of the spine showing multiple vertebral crush fractures$

Pseudofracture of the distal fibula

Multiple vertebral crush fractures

Adults with hypophosphatasia experience a large number of fractures (mean [standard deviation, SD] of 12.9 [19.0] fractures [range, 1-100]).^15,b

Pain and impaired mobility severely limit activities of daily living in adults with hypophosphatasia.¹⁵

Graphic showing that adults with hypophosphatasia reported pain (95%) and bone pain severe enough to limit activity (76%), and 69% required medication for their bone pain

Graphic showing that many adults with hypophosphatasia reported the need for mobility assistance: 60% ever used an assistive device for mobility, 34% currently use an assistive device to walk, and 21% currently use a wheelchair

Severe, chronic pain and significant disability can have a dramatic impact on quality of life in adults with hypophosphatasia.^2,3,27,28

Adults with hypophosphatasia live with significant physical function and mobility impairments.^3,15

A majority of adults with hypophosphatasia reported difficulty with activities of daily living.^15,d

Graphic showing that the majority of adults with hypophosphatasia reported difficulty with activities of daily living, including descending stairs (81%), climbing stairs (74%), standing from sitting (56%) and picking up objects from the floor (56%)

Difficulties with activities of daily living can severely impact quality of life.³

Adults with hypophosphatasia can be significantly disabled.³

Infographic showing that the majority of adult patients with hypophosphatasia reported impaired mobility

View case studies to learn about disease progression in adults with hypophosphatasia.

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^aRadiographs are from different patients with hypophosphatasia.

^bCombined data from HIPS/HOST, an Internet questionnaire and telephone survey that queried demographics, hypophosphatasia-related illness history, disease progression, and health-related quality of life. One hundred twenty-five adults participated.¹⁵

^cData from HIPS, an Internet questionnaire that queried demographics, HPP-related illness history, disease progression, and health-related quality of life. Eighty-nine adults participated.¹⁵

^dHOST was a telephone survey that queried demographics, HPP-related illness history, disease progression, and health-related quality of life. Thirty-six adults participated.¹⁵

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The devastating consequences of hypophosphatasia (HPP) are progressive and can worsen in adulthood.^1-4

Manifestations of hypophosphatasia in adults can include

Choose an icon to learn more

Skeletal manifestations of hypophosphatasia can result in a high burden of disease in adults.¹

55 years of age^23,a

56 years²⁴ of age^18,a

Bilateral acute subtrochanteric femoral fractures

Recurrent, poorly healing metatarsal stress fracture

32 years of age^25,a

55 years of age^26,a

Pseudofracture of the distal fibula

Multiple vertebral crush fractures

Pain and impaired mobility severely limit activities of daily living in adults with hypophosphatasia.¹⁵

Adults with hypophosphatasia live with significant physical function and mobility impairments.^3,15

A majority of adults with hypophosphatasia reported difficulty with activities of daily living.^15,d

Adults with hypophosphatasia can be significantly disabled.³

View case studies to learn about disease progression in adults with hypophosphatasia.

Keep Me Updated
I want to know the latest news and
information about Hypophosphatasia.

The devastating consequences of hypophosphatasia (HPP) are progressive and can worsen in adulthood.1-4

Manifestations of hypophosphatasia in adults can include

Choose an icon to learn more

Skeletal manifestations of hypophosphatasia can result in a high burden of disease in adults.1

55 years of age23,a

56 years24 of age18,a

Bilateral acute subtrochanteric femoral fractures

Recurrent, poorly healing metatarsal stress fracture

32 years of age25,a

55 years of age26,a

Pseudofracture of the distal fibula

Multiple vertebral crush fractures

Pain and impaired mobility severely limit activities of daily living in adults with hypophosphatasia.15

Adults with hypophosphatasia live with significant physical function and mobility impairments.3,15

A majority of adults with hypophosphatasia reported difficulty with activities of daily living.15,d

Adults with hypophosphatasia can be significantly disabled.3

View case studies to learn about disease progression in adults with hypophosphatasia.

Keep Me UpdatedI want to know the latest news and information about Hypophosphatasia.

The devastating consequences of hypophosphatasia (HPP) are progressive and can worsen in adulthood.^1-4

Skeletal manifestations of hypophosphatasia can result in a high burden of disease in adults.¹

55 years of age^23,a

56 years²⁴ of age^18,a

32 years of age^25,a

55 years of age^26,a

Pain and impaired mobility severely limit activities of daily living in adults with hypophosphatasia.¹⁵

Adults with hypophosphatasia live with significant physical function and mobility impairments.^3,15

A majority of adults with hypophosphatasia reported difficulty with activities of daily living.^15,d

Adults with hypophosphatasia can be significantly disabled.³

Keep Me Updated
I want to know the latest news and
information about Hypophosphatasia.