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The devastating consequences of hypophosphatasia (HPP) are progressive and can worsen in adulthood.1-4

Manifestations of hypophosphatasia in adults can include

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  • Skeletal
  • Muscular/Rheumatologic
  • Physical function
  • Dental
  • Renal
Loss of physical function impacting activities of daily living15
Unusual gait15
Impaired mobility (including the need for assistive devices such as wheelchair, walker, crutches, or cane)1,15
Alkaline phosphatase (ALP) is necessary for ongoing skeletal health because of the body’s constant bone mass turnover.1,5,21,22

Skeletal manifestations of hypophosphatasia can result in a high burden of disease in adults.1

55 years of age23,a
56 years24 of age18,a
Bilateral acute subtrochanteric femoral fractures
Recurrent, poorly healing metatarsal stress fracture
32 years of age25,a
55 years of age26,a
Pseudofracture of the distal fibula
Multiple vertebral crush fractures
Adults with hypophosphatasia experience a large number of fractures (mean [standard deviation, SD] of 12.9 [19.0] fractures [range, 1-100]).15,b

Pain and impaired mobility severely limit activities of daily living in adults with hypophosphatasia.15

Severe, chronic pain and significant disability can have a dramatic impact on quality of life in adults with hypophosphatasia.2,3,27,28

Adults with hypophosphatasia live with significant physical function and mobility impairments.3,15

A majority of adults with hypophosphatasia reported difficulty with activities of daily living.15,d

Difficulties with activities of daily living can severely impact quality of life.3

Adults with hypophosphatasia can be significantly disabled.3

View case studies to learn about disease progression in adults with hypophosphatasia.

aRadiographs are from different patients with hypophosphatasia.

bCombined data from HIPS/HOST, an Internet questionnaire and telephone survey that queried demographics, hypophosphatasia-related illness history, disease progression, and health-related quality of life. One hundred twenty-five adults participated.15

cData from HIPS, an Internet questionnaire that queried demographics, HPP-related illness history, disease progression, and health-related quality of life. Eighty-nine adults participated.15

dHOST was a telephone survey that queried demographics, HPP-related illness history, disease progression, and health-related quality of life. Thirty-six adults participated.15

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