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Children with hypophosphatasia had impaired mobility vs healthy children, as measured by the 6-minute walk test (6MWT).9,20
The 6MWT is a clinically relevant measure of disability for patients with hypophosphatasia.9
aRadiographs are from different patients with hypophosphatasia.
bData from a noninterventional, retrospective chart review study designed to understand the natural history of 48 patients ≤5 years of age with severe perinatal- and infantile-onset HPP. Patients included in the study were those diagnosed with HPP based on at least one of the following: serum biomarker levels (below-normal ALP and above-normal PLP or PEA), below-normal ALP and radiographic abnormalities, or genetic analysis of the ALPL gene. Additionally, onset of HPP must have occurred prior to 6 months of age based on signs that included at least one of the following: respiratory compromise, rachitic chest deformity, and/or vitamin B6–responsive seizures.19
cData from a retrospective, multinational, noninterventional natural history study of childhood HPP in patients 5 to 15 years of age (N=32).25
dHIPS/HOST combined data from an Internet questionnaire and telephone survey that queried demographics, hypophosphatasia-related illness history, disease progression, and health-related quality of life. Fifty-nine children participated.9
eHIPS was an Internet questionnaire that queried demographics, hypophosphatasia-related illness history, disease progression, and health-related quality of life. Forty-four children and adolescents participated.9
fData from a subset of 9-year-old boys (n=60; mean age, 9.5 years) from a larger study (N=442) intended to generate normative data for the 6MWT.9
gBaseline 6MWT data from a clinical trial in children 5 to 12 years of age with HPP (N=13; mean age, 8.8 years).20
hData from HOST, a telephone survey that queried demographics, HPP-related illness history, disease progression, and health-related quality of life. Fifteen children participated.9
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