Children with hypophosphatasia had impaired mobility vs healthy children, as measured by the 6-minute walk test (6MWT).9,20
The 6MWT is a clinically relevant measure of disability for patients with hypophosphatasia.9
Learn about disease progression in an adolescent with hypophosphatasia.
How might hypophosphatasia impact adults in your practice?
aRadiographs are from different patients with hypophosphatasia.
bData from a noninterventional, retrospective chart review study designed to understand the natural history of 48 patients ≤5 years of age with severe perinatal- and infantile-onset HPP. Patients included in the study were those diagnosed with HPP based on at least one of the following: serum biomarker levels (below-normal ALP and above-normal PLP or PEA), below-normal ALP and radiographic abnormalities, or genetic analysis of the ALPL gene. Additionally, onset of HPP must have occurred prior to 6 months of age based on signs that included at least one of the following: respiratory compromise, rachitic chest deformity, and/or vitamin B6–responsive seizures.19
cData from a retrospective, multinational, noninterventional natural history study of childhood HPP in patients 5 to 15 years of age (N=32).25
dHIPS/HOST combined data from an Internet questionnaire and telephone survey that queried demographics, hypophosphatasia-related illness history, disease progression, and health-related quality of life. Fifty-nine children participated.9
eHIPS was an Internet questionnaire that queried demographics, hypophosphatasia-related illness history, disease progression, and health-related quality of life. Forty-four children and adolescents participated.9
fData from a subset of 9-year-old boys (n=60; mean age, 9.5 years) from a larger study (N=442) intended to generate normative data for the 6MWT.9
gBaseline 6MWT data from a clinical trial in children 5 to 12 years of age with HPP (N=13; mean age, 8.8 years).20
hData from HOST, a telephone survey that queried demographics, HPP-related illness history, disease progression, and health-related quality of life. Fifteen children participated.9