Current treatment options

Medical treatment options for hypophosphatasia (HPP) are available.

Contact Medical Information for more information on hypophosphatasia patient management.

Managing hypophosphatasia

Patients with a confirmed or suspected diagnosis of hypophosphatasia should be referred to an individualized management team, which may include:

Endocrinologists

Geneticists

Orthopedists

Radiologists

Dentists

Physical therapists

Historically, management of hypophosphatasia has focused on supportive therapy to minimize disease-related systemic manifestations^1,2:

Vitamin B₆ for seizures in affected patients^1,2

Surgery to relieve intracranial pressure or repair fractures^1,2

Pain management, such as NSAIDs²

Dental care to preserve primary dentition²

High-dose vitamin D, calcium supplements, and bisphosphonates should not be given when hypophosphatasia is suspected, as they have been shown to exacerbate symptoms of hypophosphatasia.^2-4

Fractures and pseudofractures are common in patients with hypophosphatasia and can potentially be managed with surgical interventions.^1,2

Due to the unique pathophysiology of the disease, surgical repair may differ for patients with hypophosphatasia. Experts recommend managing pseudofractures secondary to hypophosphatasia by internal fixation with a load-bearing device without removal^1,5,6

$Radiograph of a right femoral pseudofracture in a patient with hypophosphatasia$

Right femoral pseudofracture⁷

Reprinted with permission from Whyte, Principles of Bone Biology, 3rd ed, 2008.

$Radiograph of a pseudofracture of the proximal femur treated with intramedullary nail fixation in a patient with hypophosphatasia$

A pseudofracture of the proximal femur (arrow) treated with intramedullary nail fixation⁸

Reprinted with permission from
Berkseth et al., 2013.

Misdiagnosis can compound the clinical consequences of hypophosphatasia

Avoid misdiagnosis

Misdiagnosis can lead to ineffective management that can compound clinical consequences.^1-4

Hypophosphatasia in a child with widened anterior fontanelle: Lessons learned from late diagnosis and incorrect treatment.

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Current treatment options

Managing hypophosphatasia

Historically, management of hypophosphatasia has focused on supportive therapy to minimize disease-related systemic manifestations^1,2:

High-dose vitamin D, calcium supplements, and bisphosphonates should not be given when hypophosphatasia is suspected, as they have been shown to exacerbate symptoms of hypophosphatasia.^2-4

Avoid misdiagnosis

Keep Me Updated
I want to know the latest news and
information about Hypophosphatasia.

Current treatment options

Managing hypophosphatasia

Historically, management of hypophosphatasia has focused on supportive therapy to minimize disease-related systemic manifestations1,2:

High-dose vitamin D, calcium supplements, and bisphosphonates should not be given when hypophosphatasia is suspected, as they have been shown to exacerbate symptoms of hypophosphatasia.2-4

Avoid misdiagnosis

Keep Me UpdatedI want to know the latest news and information about Hypophosphatasia.

Historically, management of hypophosphatasia has focused on supportive therapy to minimize disease-related systemic manifestations^1,2:

High-dose vitamin D, calcium supplements, and bisphosphonates should not be given when hypophosphatasia is suspected, as they have been shown to exacerbate symptoms of hypophosphatasia.^2-4

Keep Me Updated
I want to know the latest news and
information about Hypophosphatasia.