Understanding Hypophosphatasia (HPP)

“I’ve always known there was something. Now I know what it is.”

All patient images and quotes are hypothetical



HPP is a rare condition that can look and feel like many things: fatigue, pain, broken bones. While these symptoms may seem disconnected, HPP could be behind them all. It can also mirror symptoms found in other more common conditions like osteoporosis, osteopenia, and fibromyalgia. Important factors your doctor can look for in order to determine an HPP diagnosis include persistently low age- and sex- adjusted alkaline phosphatase (ALP) and one or more key signs or symptoms.

Learn more about alp

How to Recognize HPP

HPP has several symptoms. No matter the life stage, you can get help in recognizing the signs. See below for the differences between children and adults living with HPP.

What should I know about HPP in children?

There can be many signs of childhood HPP, so you should know what to look for. Some of the most common symptoms in children include early tooth loss with the root intact, delayed motor milestones, delayed walking, and muscle, bone, or joint pain.

How does HPP impact adults?

Adults living with HPP may experience symptoms they have already normalized as something else. If you’ve experienced early tooth loss or rickets during childhood, those could be signs of HPP. Find out how to recognize HPP now.


We’re here to help.

Sign up to stay connected and learn about disease information, community support resources, and more.

Sign Up