The short answer:
HPP is a rare, but inherited disorder.
This means multiple people in the same family may have it. If you’ve been diagnosed with HPP or have symptoms, think about encouraging your loved ones to consider their medical history and talk to a doctor as well.
For adults (18 years or older) diagnosed with HPP, symptoms can range from mild to severe. At this life stage, HPP may be associated with a number of symptoms including chronic bone pain, softening bones, and poor dentition and gum disease.
For those diagnosed with HPP as children (between the ages of 6 months and 18 years or older), symptoms can range widely. Some of the symptoms may include slow or stunted growth; difficulty doing the things other children or teenagers can do (like climbing stairs or riding a bike), broken bones, muscle pain, weakness, early tooth loss, and fatigue. Sometimes, HPP symptoms will improve on their own; other times, they can cause additional complications with age.
Occurring after birth but before the age of six months, infantile HPP is marked by low levels of ALP, poor bone formation, respiratory problems, and renal compromise, resulting in serious long-term complications.
Perinatal HPP is often the most severe form of HPP and begins in utero or at birth. It is characterized by significant bone loss and needs to be identified quickly to take action.
This makes it difficult for the body to create enough ALP enzyme to maintain adequate bone and teeth mineralization over time.
HPP isn’t limited to broken bones and difficulty moving around. As a multisystemic condition, HPP can affect many areas of the body, causing pain, fatigue, and brain fog.
Select a system below* to see how it can be affected by HPP:
†A symptom most commonly seen in infants and young children.
†A symptom most commonly seen in infants and young children.
Join a personalized patient support program to learn more about disease information, connect with other patients, and more.
