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What is alkaline phosphatase (ALP) and what does it mean for an HPP diagnosis?
All patient images and quotes are hypothetical
All patient images and quotes are hypothetical
Understanding alkaline phosphatase (ALP).
ALP is an essential enzyme that processes certain minerals in the body which help form strong bones and teeth. People with hypophosphatasia (HPP) have persistently low ALP, which often explains the frequent bone fractures, tooth loss, and chronic pain that may be experienced throughout their lives.
The connection between
low ALP
& HPP.
Persistently low ALP could be the key to an HPP diagnosis. If you’ve been experiencing symptoms of HPP, ask your doctor for a blood test, because…
Persistently low age and sex-adjusted ALP plus one more HPP symptom is enough for your doctor to confirm HPP after ruling out other causes of low ALP. This resource is for educational purposes only and does not replace a healthcare professional’s judgment or clinical diagnosis.
Testing for persistently low ALP.
Curious to know what your ALP levels are? Look back at your previous blood tests and prior medical records with your doctor. If alkaline phosphatase levels are persistently low based on your age and sex, it may indicate an HPP diagnosis.
Your numbers may help you find long-awaited answers related to your health. Check your age- and sex-adjusted ALP reference intervals (U/L)31
Select a sex to see ALP levels.
How is ALP measured?
ALP levels are measured in a standard comprehensive blood panel. It’s important for your doctor to review your test results against age and sex adjusted reference ranges in order to evaluate your ALP levels appropriately.
Do you know your alkaline phosphatase level?
Enter your age and alkaline phosphatase value from a recently administered blood test to find out more. This resource is for educational purposes and does not replace a healthcare professional’s judgement or clinical diagnosis.
Measured in U/L (Units per Liter)
Your ALP level is lower than average
for your age and sex.
Speak with your healthcare team to learn more about what this may mean for your health.
Your ALP level is in a normal range
for your age and sex. If you’re experiencing concerning symptoms, it may be helpful to speak with your healthcare team to learn more.
Your ALP level is higher than average
for your age. Speak with your healthcare team to learn more about what this may mean for your health.
This resource is not intended for use in the diagnosis of any disease or condition, or for the cure, mitigation, or treatment of any disease or condition. It does not replace a healthcare professional’s judgment or clinical diagnosis.
Adapted from the Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) project (Colantonio et al, 2012). No variation in ALP based on ethnic differences was observed. Reference intervals shown were established on the Abbott ARCHITECT C8000 analyzer.31
Check with your doctor for the appropriate age- and sex-adjusted reference range. Low ALP is not conclusive for diagnosis of HPP. Patients should be evaluated for other symptoms of HPP and differential diagnosis should be ruled out.
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