What factors can lead to a hypophosphatasia (HPP) diagnosis in adults?

While symptoms like fatigue or joint pain could be signs of HPP,
there’s one factor that will most likely confirm a diagnosis. It can feel complex, but a diagnosis doesn’t have to be complicated.

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Suzanne (left) and
Amy (center), living with hpp, And family


When my twin and I were finally diagnosed with HPP it felt validating, it felt like we had an answer to a mystery. It felt like we were right and there was a victory in following our hunches."


If you’ve lived a lifetime with unexplained, seemingly disconnected symptoms, it is time to talk to a doctor about getting a diagnosis. Ask your doctor for a simple blood test to determine if you have HPP.

It takes one or more HPP symptoms + persistently low age- and sex-adjusted ALP


Persistently low
Age- and sex-adjusted alp

HPP Symptoms

One or more HPP


May be enough for your
doctor to diagnose HPP

If you or your doctor suspects HPP based on your symptoms and history,
a blood test to check your ALP levels can confirm the diagnosis. Check with your doctor for more information, only a licensed healthcare professional can diagnose HPP.*

*After your doctor has ruled out other causes of low ALP


Seek answers. Take action.

Are you tired of your unexplained symptoms? It’s not too late to make a change.

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Know your symptoms

HPP is difficult to diagnose in adults because of shared symptoms with more common bone or rheumatologic diseases, like arthritis. But while it may seem easier to brush off or minimize your pain—especially if you’ve normalized it over your lifetime—it’s never too late to be proactive. Don’t wait another minute. Have a conversation with your doctor.


Need help finding a doctor who understands HPP?

If you’ve been struggling with symptoms you don’t understand, speaking to a healthcare provider who understands may help. Visit the doctor finder to learn more about finding an HPP specialist.

(powered by MediFind)


Get the Help You Deserve.

When going to the doctor, bring your medical records with you (if possible). Or, talk to your parents, caregiver, or older siblings to go over events and symptoms from your childhood.

Medical History or Personal Records

During your life, have you experienced unexplained fractures? Or premature tooth loss with the root intact? Every person’s medical history is unique and can be the key to unlocking an accurate diagnosis. It may be helpful to discuss or share symptoms with family members, especially if symptoms were present during childhood. Tracking your symptoms over time and sharing them with your doctor may lead to an earlier diagnosis.

Significant Medical Events

Did you experience any traumatic injuries during childhood? Any major medical milestones to note? Consult a parent or guardian, and make sure to mention these significant events to your doctor.


Write down a list of questions you have and ask them! The best way to get answers about your symptoms—and potential diagnosis—is to have an open, honest conversation with your doctor.
The Hypophosphatasia Journal can be used to track symptoms, appointments, and more.

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