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Can a doctor tell me why my body feels this way?”

Even though hypophosphatasia (HPP) is a rare condition, a simple blood test can provide the answer:
Persistently low age- and sex-adjusted alkaline phosphatase (ALP), plus one or more HPP symptoms, may be enough for your doctor to confirm an HPP diagnosis.* Check with your doctor for more information. Only a licensed healthcare professional can diagnose HPP.

*After your doctor has ruled out other causes of low ALP

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Amy, living with HPP

What is alkaline
phosphatase (ALP)?

ALP is an enzyme in the body that is crucial for the development of strong, healthy bones. People with HPP have persistently low ALP, which contributes to many symptoms of the condition, including frequent fractures. It’s important to adjust for age and sex when assessing ALP to arrive at the most accurate possible reference range, especially in children.

More on ALP
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If you think you may have HPP, I would recommend to start by going to your primary care doctor. Ask for the routine bloodwork that has alkaline phosphatase (ALP) in it.”


Watch Amy and Suzanne’s video to learn more about their experience searching for a diagnosis.

How do I know if my diagnosis is

HPP can be
misdiagnosed as these conditions.

In adults, HPP may be mistaken
for other more common conditions.
If you feel something is wrong, and believe your symptoms could mean something more, don’t settle. HPP can be diagnosed with the help of a blood test.

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Chronic Conditions


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Bone Pain

Osteogenesis Imperfecta
Rheumatoid Arthritis

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Dental Conditions

Gum Disease
Dentinogenesis Imperfecta

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Bone Cancer

What steps can I take with my child’s doctor to test my child for HPP?

Having a child who doesn’t gain weight, grow on pace, or meet expected milestones can be a sign that something’s not right. Ask your child’s doctor for a blood test to determine if your child has persistently low ALP

Take Action for Your Child
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