For Valuable Updates and Resources

Hypophosphatasia (HPP) causes progressive and devastating systemic consequences in patients of all ages.1

As a result of low alkaline phosphatase (ALP) activity and defective bone mineralization, patients may experience a variety of signs and symptoms throughout life.1-4


  • Premature loss of deciduous or adult teeth1,5,6
  • Abnormal dentition1
  • Periodontal disease7,8
Rachitic chest and hypoplastic lungs are respiratory symptoms of hypophosphatasia


In infants:

  • Pulmonary hypoplasia1,9
  • Respiratory insufficiency1,2,9
  • Need for ventilation support1,10
Fractures and skeletal deformity are skeletal symptoms of hypophosphatasia


  • Hypophosphatasia-induced rickets11,12
  • Skeletal deformities1
  • Osteomalacia13
  • Osteopenia/ osteoporosis1,14
  • Fractures15-17
  • Bone pain1
Craniosynostosis and vitamin B6–responsive seizures are neurologic symptoms of hypophosphatasia


  • Vitamin B6-responsive seizures18
  • Neurologic consequences of craniosynostosis19
Hypercalcemia and hypercalciuria are renal symptoms of hypophosphatasia


  • Nephrocalcinosis1,20
  • Progressive renal damage21-23
  • Renal failure21


  • Muscle weakness1,24,25
  • Calcium pyrophosphate dihydrate (CPPD) deposition disease/pseudogout/ chondrocalcinosis1,26,27
  • Muscle and joint pain1,24,28

Symptoms for hypophosphatasia may appear at any age and may worsen over time.1,4,31,32

Learn More

About the progressive nature of hypophosphatasia.

By clicking "SUBMIT" I agree to the Privacy Notice and Terms of Use.