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Adolescent Case

Delayed growth along with skeletal and dental manifestations in a male child with hypophosphatasia1

A young man with hypophosphatasia experiences progressive disease throughout childhood.

Children with hypophosphatasia can experience progressive systemic manifestations that can persist into adulthood.2-5

Based on a published case study: Watanabe et al, J Periodontol, 1993.

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  1. Watanabe H, Umeda M, Seki T, Ishikawa I. Clinical and laboratory studies of severe periodontal disease in an adolescent associated with hypophosphatasia. A case report. J Periodontol. 1993;64(3):174-180.
  2. Rockman-Greenberg C. Hypophosphatasia. Pediatr Endocrinol Rev. 2013;10(suppl 2):380-388.
  3. Weber TJ, Sawyer EK, Moseley S, Odrljin T, Kishnani PS. Burden of disease in adult patients with hypophosphatasia: results from patient-reported outcome surveys. Poster presented at: Endocrine Society Annual Meeting; March 5-8, 2015; San Diego, CA.
  4. Caswell AM, Whyte MP, Russell RGG. Hypophosphatasia and the extracellular metabolism of inorganic pyrophosphate: clinical and laboratory aspects. Crit Rev Clin Lab Sci. 1991;28(3):175-232.
  5. Birtwell WM Jr, Riggs BL, Peterson LFA, Jones JD. Hypophosphatasia in an adult. Arch Intern Med. 1967;120(1):90-93.